Cell Biology by the Numbers by
"Very little in our human experience is truly comparable to the immensely crowded and bustling interior of a cell. Biological numeracy provides a new kind of understanding of the cellular world. This book brings together up-to-date quantitative data from the vast biological literature and uses the powerful tool of "back of the envelope" estimates to reveal fresh perspectives and insights from numbers commonly encountered in cell biology. Readers gain a feeling for the sizes, concentrations, energies, and rates that characterize the lives of cells - thereby shedding new light on the microscopic realm." -- Publisher's description
Targeting Cancer by
The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genesand Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth and Progression; Innate and Adaptive Immune Responses; andEnabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.
The Good, the True, and the Beautiful: A Neuronal Approach by
"In this fascinating and bold discussion, a renowned neurobiologist serves as guide to the most complex physical object in the living world: the human brain. Taking into account the newest brain research--morphological, physiological, chemical, genetic--and placing these findings in the context of psychology, philosophy, art, and literature, Changeux ventures into the unexplored territories where these diverse disciplines intersect.Changeux's book draws on Plato's notion that the Good, the True, and the Beautiful are celestial essences or ideas, independent but so intertwined as to be inseparable. Placing these essences within the characteristic features of the human brain's neuronal organization, the author addresses unsolved questions in neuroscience today. With imagination and deep insight, Changeux illuminates the evolution of the brain and deciphers what new developments in neuroscience may portend for the future of humanity"--Provided by publisher.
Metabolism and Disease by
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding of metabolism and disease, including research on fat, exercise and rhythms; insulinresistance and sensitivity; lifespan, aging and cancer; regulation and dysregulation of metabolism; signaling and gene regulation; environment and sensing; metabolic reprogramming; clocks and intermediary metabolism; metabolism and cancer; and autophagy, timing and small RNAs.
Cell Physiology Source Book: Essentials of Membrane Biophysics by
Cell Physiology Source Book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The 4e contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics Full color illustrations
Cell Proliferation by
Cellular proliferation, as a result of cell growth and cell division, is one of the most fundamental biological processes. Although there is a great deal which remains unclear, significant advances have been made in past decades in our understanding of the process and regulation of cell proliferation. There is considerable evidence that this understanding of different cells and cell proliferation behavior provides useful information that may be of major importance in disease control, drug discovery, biomaterial development and medical device improvement. This book studies and discusses recent developments in the field of cell proliferation including: the controlling factors for cell proliferation; changes occurring in the cells; therapeutic effects of the biological molecules to the cells; and analysis of cell proliferation based on the quantal concept. Furthermore, the effects that biomaterials and drugs have on cell proliferation are also reviewed in this book.
Protein Families by
New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover, they'll discover how these systems can be used to understand the evolution of protein families as well as understand and predict the degree to which structural and functional information are shared between relatives in a protein family. Edited and authored by leading international experts, Protein Families offers new insights into protein families that are important to medical research as well as protein families that help us understand biological systems and key biological processes such as cell signaling and the immune response. The book is divided into three sections: Section I: Concepts Underlying Protein Family Classification reviews the major strategies for identifying homologous proteins and classifying them into families. Section II: In-Depth Reviews of Protein Families focuses on some fascinating super protein families for which we have substantial amounts of sequence, structural and functional data, making it possible to trace the emergence of functionally diverse relatives. Section III: Review of Protein Families in Important Biological Systems examines protein families associated with a particular biological theme, such as the cytoskeleton. All chapters are extensively illustrated, including depictions of evolutionary relationships. References at the end of each chapter guide readers to original research papers and reviews in the field. Covering protein family classification systems alongside detailed descriptions of select protein families, this book offers biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new insight into the evolution and nature of proteins.
Osteoblasts by
Osteoblasts are highly specialized mesenchymal cells that are mainly responsible for the formation and maintenance of the skeletal architecture. They produce extracellular matrix proteins and are regulators of matrix mineralization during bone formation and remodeling. In this book, the authors discuss the morphology, functions and clinical implications of osteoblasts. Topics include osteoblasts under mechanical strain; mesenchymal stem cells (MSC) into osteoblasts for bone tissue engineering; osteoblast function and their role in skeletal bone diseases; bone morphogenetic proteins (BMP) and osteoblastogenesis inhibitors; the effect of molecular and biochemical differentiation agents on bone formation; and the evaluation of characteristics of osteoblasts and factors related to osteoblastic differentiation and mineralization.
Mining the Biomedical Literature by
A concise introduction to fundamental methods for finding and extracting relevant information from the ever-increasing amounts of biomedical text available The introduction of high-throughput methods has transformed biology into a data-rich science. Knowledge about biological entities and processes has traditionally been acquired by thousands of scientists through decades of experimentation and analysis. The current abundance of biomedical data is accompanied by the creation and quick dissemination of new information. Much of this information and knowledge, however, is represented only in text form--in the biomedical literature, lab notebooks, Web pages, and other sources. Researchers' need to find relevant information in the vast amounts of text has created a surge of interest in automated text-analysis. In this book, Hagit Shatkay and Mark Craven offer a concise and accessible introduction to key ideas in biomedical text mining. The chapters cover such topics as the relevant sources of biomedical text; text-analysis methods in natural language processing; the tasks of information extraction, information retrieval, and text categorization; and methods for empirically assessing text-mining systems. Finally, the authors describe several applications that recognize entities in text and link them to other entities and data resources, support the curation of structured databases, and make use of text to enable further prediction and discovery.
Molecular and Cellular Therapeutics by
Molecular and Cellular Therapeutics aims to bring together key developments in the areas of molecular diagnostics, therapeutics and drug discovery. The book covers topics including diagnostics, therapeutics, model systems, clinical trials and drug discovery. The developing approaches to molecular and cellular therapies, diagnostics and drug discovery are presented in the context of the pathologies they are devised to treat.
Genetic Diagnoses by
This book presents current research from across the globe in the study of genetic diagnoses. Topics discussed include the genetic risk factors between thyroid function and preeclampsia; the molecular diagnosis of thalessemia and spinocerebelar ataxias; the genetics of left ventricular noncompaction; the genetic diagnosis to type 1 diabetes and the genetics of congenital heart disease
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